Leukocyte Chemotaxis and Migration
نویسندگان
چکیده
منابع مشابه
Leukocyte chemotaxis and migration: can we follow the cells?
A CRITICAL feature of the innate immune response is the movement of neutrophils and macrophages from one site in the body to another to provide effector functions. These immune cells play a critical role in fighting infection but may also cause damage to parenchymal cells by releasing oxidants and proteases. Although the molecular mechanisms of leukocyte chemotaxis during inflammation have been...
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Cell migration is essential in species ranging from bacteria to humans (for recent reviews, see Lauffenburger and Horwitz 1996; Mitchison and Cramer 1996; Montell 1999). In the amoebae Dictyostelium discoideum, cell migration is involved in chemotaxis toward food sources and in aggregation (for review, see Devreotes and Zigmond 1988; Parent and Devreotes 1999; Chung et al. 2001). In higher vert...
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Polymorphonuclear leukocyte (PMN) locomotion and chemotaxis have been evaluated by direct microscopic observation of individual cells in thin slide-cover slip preparations, and also by observations on populations of cells migrating into a Millipore filter. The direct microscopic method used the polarity of the locomoting PMNs (broad, advancing lamellipodium and knoblike constriction at the rear...
متن کاملA 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration.
We designed a 48-well chemotaxis chamber to minimize manipulation time and amount of material required by the larger blindwell or Boyden chemotaxis chamber. Cell and chemoattractant dose-response curves showed that results were comparable to our better than those obtained with blindwell chambers. The volume of chemoattractant per well is 25 microliter; the number of cells can be as low as 10,00...
متن کاملPolymorphonuclear leukocyte functions enhanced by chemotaxis.
Human polymorphonuclear leukocytes (PMN) migrate into tissues in response to chemoattractants, yet it is not known whether this process alters the functional capabilities of the PMN. Using recombinant human interleukin-8 (rHIL-8, 100 ng/ml) as a stimulus, we compared a population of PMN that migrated through a polyvinylpyrrolidone-coated polycarbonate filter containing 8.0 microns diameter pore...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2010
ISSN: 0003-3022
DOI: 10.1097/aln.0b013e3181e99c1a